Cholestérol, cœur et statines: réel progrès ou "fake news" ?

Cholesterol poses a risk to the heart, a risk that is reduced by the use of statins, "anti-cholesterol" molecules. But is this true, and if so, why, how, when, and what are the uses of these drugs? Cholesterol becomes dangerous when it is oxidized—actually, when the proteins that carry it in the blood, called apolipoproteins, are oxidized. This oxidation comes from free radicals, which are derived from the oxygen we breathe. We have a variety of white blood cells, called macrophages, which have receptors on their surface capable of capturing oxidized LDL. And when there are too many of them, these lipids are deposited in the artery walls, and this is called atheromatous plaque. There are generally two strategies for reducing the amount of oxidized LDL: either eat five fruits and vegetables a day, a diet rich in antioxidants, but which is somewhat disappointing in this regard, or take medications that inhibit the synthesis of cholesterol and its transporters, which are very effective. As with any treatment, there are side effects, such as muscle cramps. This treatment should be discussed with the patient, based on the expected benefits and known adverse effects. #lifestyleandhealth #cholesterol #statins 00:00 introduction 01:30 cholesterol: oxidation and transport 03:48 oxidized cholesterol: the consequences 05:18 oxidized cholesterol: preventive strategies 06:57 cholesterol: statins 10:29 statins, in practice