CISTO: Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade NMIBC

At the AUA 2025 Annual Meeting, John Gore, MD, MS, Fred Hutchinson Cancer Center, offers some interesting data from the CISTO study, an investigation into radical cystectomy versus bladder-sparing therapy for recurrent high-grade NMIBC. Dr. Gore breaks down how they compare in terms of cancer-specific outcomes, what the results suggest about which patients may still benefit most from early cystectomy versus those who can pursue bladder-sparing approaches, and the immediate implications for clinical practice.