La Presentación Antigénica | 34/56 | UPV

Title: Antigen Presentation Description: Detailed description of the processing of intracellular and extracellular antigens and how they initiate the immune response. Sirera Pérez, R. (2016). Antigen Presentation. https://riunet.upv.es/handle/10251/66623 DER Automatic description: In this video, a professor from the biotechnology department of the Polytechnic University explains the concept of antigen presentation and its importance as a link between innate and adaptive immunity. He focuses on how immune cells recognize and respond to extracellular and intracellular threats, including pathogens and neoplastic cells. Discussing the participants in antigen presentation, the video highlights antigen-presenting cells (APCs) and the role of nucleated cells in signaling helper T cells and cytotoxic T lymphocytes (CD8) about the cellular processes occurring within them. The video outlines the molecular mechanisms involved, such as the major histocompatibility complex (MHC) and T cell receptors (TCRs), as well as the protein degradation processes necessary for antigen presentation. The video outlines the risk categories associated with different antigens and describes how antigen-presenting cells (APCs) process extracellular microorganisms to present them to CD4 cells via MHC class II. It also details how CD4 cells assist B cells in producing antibodies and activating cytotoxic T lymphocytes. Furthermore, it addresses the identification of and response to intracellular pathogens or cell transformations, noting how nucleated cells use MHC class I to present protein fragments to CD8 cells. The distinction between naive and effector CD8 cells and the need for costimulatory molecules for their activation are explained. In conclusion, the video emphasizes the crucial role of antigen presentation in enabling helper T cells and cytotoxic T lymphocytes to identify both extracellular and intracellular antigens, and distinguishes between the roles of MHC class I and II in this process. Author: Rafael Sirera Pérez Course: This video is 10/25 of the MOOC course Immune Response Part II. Molecules that Recognize Antigens.    • MOOC Respuesta inmunitaria Parte II. Moléc...   Enroll at: https://upvx.es/courses/course-v1:Mic... Course: This video is 34/56 of the Immunology course.    • Inmunología   Universitat Politècnica de València (UPV): https://www.upv.es More videos at:    / valenciaupv   Access our MOOCs: https://upvx.es #Presentation #Antigen #Phagocytosis #MHC #Lysosome #Proteasome #MICROBIOLOGY #2412 - Immunology