El complejo principal de histocompatibilidad | 38/56 | UPV

Title: The Major Histocompatibility Complex Description: Description of the major histocompatibility complex. Sirera Pérez, R. (2016). The major histocompatibility complex. https://riunet.upv.es/handle/10251/66483 DER Automatic description: This video addresses the study of the major histocompatibility complex (MHC) and its relationship with T lymphocytes in the antigen recognition process. It explains that T lymphocytes require MHC to interact with peptide antigens, as they do not recognize antigens in isolation. The MHC, a molecule on our cells, presents these antigens to T lymphocytes through a specific domain, while other MHC domains are related to individual genetic characteristics, exhibiting variability within the population. T lymphocytes possess a T cell receptor (TCR) that must recognize both the antigen and polymorphic MHC residues to activate the T cell, a concept known as TCR MHC restriction. The video details the existence of two classes of MHC: class I, which is expressed on all nucleated cells in the body, and class II, present only on phagocytic cells and activated B lymphocytes that act as antigen-presenting cells. The structural differences between the two classes are described, highlighting that class I is composed of alpha subunits and the non-transmembrane molecule beta-2-microglobulin. In contrast, class II is a heterodimeric molecule with alpha and beta subunits anchored to the membrane. Both classes contain polymorphic domains critical for TCR recognition. In conclusion, the video underscores the importance of the MHC in the presentation of peptide antigens to T lymphocytes, constituting an essential mechanism for specific immune activation and genetic variability among individuals. Author: Rafael Sirera Pérez Course: This video is 11/25 of the MOOC course Immune Response Part II. Molecules that Recognize Antigens.    • MOOC Respuesta inmunitaria Parte II. Moléc...   Enroll at: https://upvx.es/courses/course-v1:Mic... Course: This video is 38/56 of the Immunology course.    • Inmunología   Universitat Politècnica de València (UPV): https://www.upv.es More videos at:    / valenciaupv   Access our MOOCs: https://upvx.es #Presentation #Antigen #Proteasome #MHC #Genetics #MICROBIOLOGY #2412 - Immunology