Scientists Discuss Longevity Interventions & Optimisms | 45 - K-Lab Reunion

Subscribe to our channel:    / @matt.kaeberlein   Related episode: The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP:    • The Two New Highest Ranked Compounds For L...   Matt, who ran the Kaeberlein lab at the University of Washington from 2006 to 2023, rounded up several former lab members for a chat at the recent 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin. The group included assistant and tenured professors at various institutions around the United States, startup founders, and prospective PhD students with geroscience research interests that span the microbiome, mitochondrial dysfunction, frailty, metabolism, sex differences in aging, and more. In this episode, Matt and his former lab members pool their collective knowledge to engage in a lively conversation (and sometimes debate) about longevity interventions such as metformin, acarbose, and sauna use. In their discussion, they touch on hot-off-the-press positive results, unpublished data, and planned research from their respective research groups and labs. They also bring up nuances to recent published work, including results from the Interventions Testing Program on various interventions that Matt discussed in a previous podcast episode. 0:00 Introduction 1:07 Lab member introductions 10:49 Let's grade interventions: for, against, don't know 11:19 Methylene blue 12:31 Dasatinib and quercetin (D + Q) 13:51 Caffeine 14:04 Protein restriction 15:02 Branched-chain amino acid restriction 17:07 Hyperbaric oxygen therapy 19:04 Sauna 19:34 Cold plunges 21:48 Parabiosis 25:52 NAD+ 26:52 AKG 29:55 Metformin 32:20 GLP-1 agonists 34:00 Resveratrol 35:02 Rapamycin 36:07 Acarbose 36:39 3-hydroxyanthranilic acid (3HAA) 37:05 ORB-1284 37:34 The weirdest thing you've ever done for your longevity 46:50 Wrapping up Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter:   / optispanpodcast   Twitter:   / optispan   Twitter:   / mkaeberlein   Linkedin:   / optispan   https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!