Longevity Science 2024: New Insights on "The Hallmarks of Aging" & What They Mean | 14 - LS #5

Subscribe to our channel:    / @optispan   Over a decade ago, five researchers published a paper proposing the Hallmarks of Aging paradigm: a set of cellular and molecular processes that underlie the aging process in different organisms. These hallmarks encompass a range of interconnected pathways, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient signaling, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Together, the hallmarks contribute to the gradual decline in physiological function and increased susceptibility to age-related diseases that occurs with age, and provide a framework for understanding how we age. In this episode, Matt takes us through a quick download of each hallmark of aging, talks about some of the paradigm's shortcomings and limitations, and discusses the implications of the Hallmarks of Aging paradigm for the geroscience field. 0:00 Trailer 0:44 Introduction 2:30 Definition of the hallmarks of aging 4:40 Criteria 1: Age-associated manifestation 6:43 Criticisms of the hallmarks of aging 8:36 The current version of the hallmarks of aging 9:00 Genomic instability 10:27 Telomere attrition 12:40 Epigenetic alterations 15:32 Loss of proteostasis 17:40 Disabled macroautophagy 20:17 Deregulated nutrient signaling 21:57 Mitochondrial dysfunction 23:13 Cellular senescence 27:13 Stem cell exhaustion 29:50 Altered intercellular communication 30:47 Chronic inflammation + "inflammaging" 32:09 Dysbiosis 33:43 The interconnectedness of hallmarks 35:48 Our rudimentary understanding of biological aging 40:37 Advice for the field 40:48 Pillars of aging and their impact on the aging process Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter:   / optispanpodcast   Twitter:   / optispan   Twitter:   / mkaeberlein   Linkedin:   / optispan   https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!