Krebsmutationen: EGFR - das Protein, das die Krebswelt änderte.

The holiday season... With a considerable delay, we are now dedicating ourselves to the mutations that once turned #cancer therapy completely inside out: #EGFR mutations. Here we are mainly dealing with #lungcancer - although there are EGFR mutations in other types of cancer, especially glioblastoma, ACTIVATING mutations in the kinase domain are definitely a domain of NSCLC. Here we are no longer talking about individual active ingredients with a possible effect, but about generations of inhibitors - which shows how long we have been dealing with this (almost 20 years!). In the video, we always speak of the 3rd generation inhibitors in the plural, but all statements refer to osimertinib. The reason for this is that there are a number of similarly potent inhibitors of this generation, but none is better than osimertinib, which is why it is the only approved inhibitor of this generation in Europe and the USA. In this video, we have not yet dealt with resistance and subsequent therapy sequences. We'll take a closer look at that in another video. Unfortunately, the 15-minute upper limit could not be observed in this video - sorry, the target length remains the same for all videos of the "cancer mutations"... DISCLAIMER: In this video we use the word "molecule" very "freely" and chemically not quite correctly, e.g. T. as a synonym for "protein" - this is not intended, we apologize! If you or acquaintances are affected, we recommend contacting the following association: https://www.zielgenau.org - German association for patients with lung cancer and mutations that can be specifically treated. 00:00 Cancer mutations: EGFR 00:13 What is that actually? [SKIP INTRO] 07:23 Which types of cancer are affected? 08:23 Where does that come from? 09:52 How do you treat that? 19:18 What is the research doing? Our HER family video:    • Rezeptoren bei Krebs Basics I: Die HER-Fam...   Our video on receptor tyrosine kinases:    • Was ist Krebs: Rezeptor-Tyrosin-Kinasen   Our video on TP53 mutations:    • Krebsmutationen: TP53 - Der Wächter des Ge...   Our video on KRAS mutations:    • Krebsmutationen: KRAS - The Ancient Enemy.   __________________________ Created with: Microsoft PowerPoint, Ecamm Live Edited with: Final Cut Pro Music: "368" by Jobii [Epidemic Sound] Artwork: HealthCareSocialMedia