Dureza E Friabilidade

Hardness Determination: This test determines the tablet's resistance to crushing or rupture under radial pressure. The hardness of a tablet is proportional to the compression force and inversely proportional to its porosity (the more porous, the lower its hardness). The test is mainly applied to uncoated tablets. The test consists of subjecting the tablet to the action of a device that measures the force, applied diametrically, necessary to crush it. The force is measured in newtons (N). Friability Test: The friability test determines the resistance of tablets to abrasion when subjected to the mechanical action of specific equipment. The test applies only to uncoated tablets. HOW TO PERFORM THE TEST? a) Hardness: The test is performed with 10 tablets, removing any surface residue before each determination. The tablets are tested individually, always following the same orientation (consider the shape, presence of grooves and engraving). Express the result as the average of the values ​​obtained in the determinations. The test result is informative. b) FRIABILITY: The test consists of accurately weighing a determined number of tablets, subjecting them to the action of the apparatus, and removing them after 100 rotations. After removing any powder residue from the tablets, they are weighed again. The difference between the initial and final weight represents the friability, measured as a percentage of powder lost. For tablets with an average weight equal to or less than 0.65 g, use 20 tablets. For tablets with an average weight greater than 0.65 g, use 10 tablets. Accurately weigh the tablets and introduce them into the apparatus. Adjust the speed to 25 rotations per minute and the test time to four minutes. After the time has elapsed, remove any powder residue from the surface of the tablets and weigh again. No tablet should be broken, chipped, cracked, or split at the end of the test. Tablets with a loss equal to or less than 1.5% of their weight, or the percentage established in the monograph, are considered acceptable. If the result is doubtful or if the loss exceeds the specified limit, repeat the test twice more, considering the average result of the three determinations in the evaluation. If you work or study in the area of ​​Pharmaceutical Quality Control, especially in the pharmaceutical sector, this video is essential to understand how regulations ensure that medicines follow rigorous quality standards. 📌 Drug Quality Control Playlist: [   • Controle de Qualidade de Medicamentos  ] ✅ Link to the Brazilian Pharmacopoeia 6th Edition - Volume 1 [https://www.gov.br/anvisa/pt-br/assun...] ✅ Don't forget to subscribe to the channel and activate the bell for more content on quality control! 🔔 Follow me on social media for daily updates: [https://www.instagram.com/prof.ricard...] #BrazilianPharmacopoeia #QualityControl #Medicines #Pharmacy #GoodPractices #PharmacyChannel