5.2 VDJ Recombination Part 2 (Immunology 2025)

Explore the molecular mechanisms that drive immunoglobulin gene rearrangement through V(D)J recombination. This video examines how RAG enzymes recognize recombination signal sequences (RSSs) to cut and join DNA, and how enzymes such as TdT introduce junctional diversity to vastly expand the immunoglobulin repertoire. This video series is part of an Immunology course offered by Rutgers University in Fall 2025. Some figures were made in Biorender. No content has been monetized or otherwise designated for commercial purposes by the poster. #vdjrecombination #antibody #immunology #scienceeducation