Rose Gelineau-Morel | Precision Dosing in Dystonic CP | MPRINT 2026 | Day 1

Development of a Precision Dosing Model for Trihexyphenidyl in Children with Dystonic Cerebral Palsy Presented by Rose Gelineau-Morel, MD Assistant Professor of Pediatrics Children’s Mercy Hospital Recorded 4/13/2026 at the 2026 MPRINT Annual Meeting. In this presentation, Dr. Rose Gelineau-Morel discusses the development of precision dosing strategies for trihexyphenidyl in children with dystonic cerebral palsy. The talk reviews the clinical burden of dystonia, limitations of current treatment approaches, and the need for individualized therapeutic strategies in pediatric neurologic populations. Dr. Gelineau-Morel describes ongoing research examining the pharmacokinetics, metabolism, and stereoselective effects of trihexyphenidyl, with particular focus on CYP2D6 and CYP2C19 variability and their impact on treatment response and adverse effects. The presentation also highlights efforts to improve pediatric clinical trial participation through remote sampling, inclusive study design, and patient-centered research approaches. About MPRINT: About MPRINT: The Indiana CTSI Pharmacometric Modeling and Simulation Program and Maternal Pediatric Precision in Therapeutics Hub (MPRINT Hub) supports collaboration, education, and research in pharmacometrics, model-informed drug development, translational science, and clinical pharmacology. Conference details: Event: MPRINT Annual Meeting 2026 Day: 1 Date: April 13, 2026 Location: Hine Hall, Indianapolis, IN Chapters: 00:00 Introduction 00:36 Research overview and clinical focus 01:28 Understanding dystonia 04:28 Current treatment limitations 05:11 Precision medicine framework 08:32 Trihexyphenidyl and targeted therapeutics 12:16 Pharmacokinetics and metabolism 16:03 Pediatric PK study design 18:18 Preliminary findings 20:21 Research inclusivity and participation barriers 24:02 Audience Q&A Accessibility: Captions/subtitles are available for this video. Disclaimer: The views and opinions expressed in this presentation are those of the speaker and do not necessarily reflect those of Indiana University, Purdue University, the Indiana CTSI, or affiliated organizations.