Метипред и гидроксихлорохин (Плаквенил) при беременности, влияние метипреда на плод.

Sign up for a consultation at the Center for Infertility and Reproduction (CIR) https://clck.ru/3QsB5D Join our chat on Telegram https://t.me/+oMLMs1FrWzliMzFi ​ In this video, Dr. Guzov, founder of the CIR, answers the question: "I'm 39 years old, 6 weeks pregnant, weigh 42 kg, height 155 cm, and my blood pressure has always been 90x60. Antiphospholipid syndrome (APS): elevated antibodies to cardiolipin, annexin, and borderline glycoprotein. Chronic endometritis was treated with two courses of antibiotics and physical therapy. My first successful birth. Subsequently, I had three missed miscarriages. I'm prescribed Metipred. How does it affect the fetus, and under what circumstances can the dose be reduced? My brown spotting hasn't stopped, and I've been prescribed Immunovenin. What's your opinion on this medication? How does it affect the fetus and, in general, the woman's body? I don't take it." Iron, but the results are 90. What could this be related to? Where should I look? Leukocytes, lymphocytes, and ESR are normal! Here, the severe weight loss is striking. 42 kg is just within the normal range for pregnancy. So, on the one hand, it's good that you're so petite, but on the other, of course, we need to look for any underlying causes that could be causing the weight gain issue. They can be complex, and I'd like to point this out. Regarding antiphospholipid antibodies, they're in the weakly positive, gray zone, especially for glycoprotein-1, which has borderline values. This is an extremely important indicator, the most important in this entire block. Because antibodies to glycoprotein-1 are antibodies against the placenta. The glycoprotein-1 protein is expressed on the outer surface of the trophoblast. Therefore, if there are antibodies, they, accordingly, attach to the trophoblast, and then a reaction is triggered in the same area, where it occurs. Antigen-antibody interactions, activation of the complement system, and the destruction of these cells occur. We can lose such a pregnancy. The basic drug that improves the prognosis of early pregnancy with this ratio of parameters is aspirin. That is, we always start with it and always prescribe it. But in some cases, it may be insufficient. Then, we block excessive activation of the complement system by prescribing a drug called hydroxychloroquine. This drug is completely safe for pregnancy at the prescribed doses. It blocks the destruction of trophoblast cells and allows us to avoid the administration of glucocorticoid hormones. Methylprednisolone is a drug that does not usually cause any serious abnormalities in the fetus, but it sends a false signal to the developing fetus that it is imitating a signal as if the mother's body is under stress for the baby. Consequently, the functional maturation of the fetal organs and systems changes slightly in anticipation of the baby's birth. In a very difficult, stressful situation. This can create long-term, hidden, and unobvious effects on the child's health, which are considered a fetal origin of adult disease. This means an increased risk of obesity, hypertension, type 2 diabetes, and some other conditions that develop in adulthood, without anyone realizing it could be related to pregnancy itself. Watch this video to the end! We're on VKontakte https://vk.com/socialnetcir Our Rutube https://rutube.ru/channel/23913594/ Our Yandex Zen https://vk.cc/cc19Fc The Center for Immunology and Reproduction (CIR) is a network of fertility, obstetrics, and prenatal diagnostics clinics with its own medical testing laboratory, "CIR Laboratories." We've been in business since 1996. Main areas of activity: Diagnosis and treatment of infertility and miscarriage IVF preparation pregnancy planning and management urology and andrology care and prevention of severe pregnancy complications, preeclampsia, APS, thrombophilia all types of tests. We help people become parents even in the most difficult cases! Our channel is dedicated to obstetrics, gynecology, and reproductive medicine. We publish videos about medical news, reviews of articles from international scientific journals, analyses of complex clinical cases, and also answer subscribers' questions in our videos. Our videos will be useful for doctors of various specialties whose work is related to reproductive medicine, as well as for patients and the general public interested in obstetrics and gynecology and seeking answers to their questions. Our channel hosts live broadcasts with Igor Ivanovich Guzov, MD, PhD, obstetrician-gynecologist, in which he talks about Medical news and answers your questions. Subscribe to our channel to stay up to date with broadcasts and new videos! This video:    • Метипред и гидроксихлорохин (Плаквенил) пр...   Other videos about autoimmune diseases and APS: https://vk.cc/9V5iTD Many interesting videos: https://goo.gl/64X3c1 ​ #CIR #Guzov #gynecology #autoimmunediseases #hydroxychloroquine #methylprednisolone