NGBS2021: Liquid-like chromatin organization from multiscale modelling – Rosana Collepardo [TALK 5]

Liquid-like chromatin organization from multiscale modelling Speaker: Rosana Collepardo, University of Cambridge UK. Chair: Maria Flocco, AstraZeneca, UK. Co-Chair: David Rueda, Imperial College London. Rosana Collepardo describes a multiscale computation approach to gain insights into chromatin organization and overcome a “blind spot” within current structure biology resolution. Building on atomistic molecule dynamics of nucleosomes through chemically-specific coarse-grained models to minimal molecular dynamic simulations of chromatin reveal how changes in modification and interactions at the nucleosome level leads to a liquid-liquid phase separated model of chromatin. This uncovers not only the complexity of chromatin structure but also the biophysical and molecular factors dictating genome organization. Read more about Rosana’s work here: http://www.collepardolab.org/ You can find more about the Next Generation Biophysics Symposium 2021 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...