NGBS2021: Single-molecule insights for drug discovery and development - Sabrina Leslie [TALK 8]

Single-molecule insights for drug discovery and development: the next level of resolution Speaker: Sabrina Leslie, University of British Columbia, Canada. Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UK. Co-Chair: Maria Flocco, AstraZeneca, UK. Sabrina Leslie describes how convex lens induced confinement (CLiC) is used to characterise single molecule lipid nanoparticles containing RNA drugs. She details how this technique enabled measurement of how much RNA is loaded within the nanoparticles by correlating size with intensity or by photo-bleaching. As a first step to understand how these nanoparticles will fuse with cells, fusion between loaded lipid nanoparticles was examined using FRET-based measurements. Read more about Sabrina’s work here: https://leslielab.msl.ubc.ca/ You can find more about the Next Generation Biophysics Symposium 2021 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...