GLUCOGÉNESIS (síntesis de glucógeno) [pasos y regulación]

#glycogen #glycogenesis #carbohydrates ►Contents: 0:00 Intro 0:15 What is glycogen? 2:45 Enzymatic steps 6:28 Regulation of glycogenesis 7:23 Final considerations ►Additional information: -When we refer to muscle, we are mainly referring to skeletal muscle. -Glycogenin exists in two isoforms: glycogenin-1 (mainly in muscle) and glycogenin-2 (liver). -Glycogenin remains in the core of the glycogen granule. -Glucose-6-phosphate is a positive allosteric regulator of the enzyme glycogen synthase. -There are approximately 19 inherited diseases related to the loss of the ability to break down or form glycogen. However, these are very rare diseases. ►Sources used to create the video: -Patino SC, et al. Biochemistry, Glycogenesis. Treasure Island (FL): StatPearls Publishing; 2021. -Sadiku P, et al. Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis. Cell Metabolism. 2021;33(2):411-423.e4. -Zhang H, et al. Beyond energy storage: roles of glycogen metabolism in health and disease. FEBS Journal. 2021;288(12):3772-3783. -Daghlas SA, et al. Biochemistry, Glycogen. Treasure Island (FL): StatPearls Publishing; 2021. -Molares-Vila A, et al. Biomarkers in Glycogen Storage Diseases: An Update. International Journal of Molecular Sciences. 2021;22(9):4381. -Visuttijai K, et al. Glycogenin is Dispensable for Glycogen Synthesis in Human Muscle, and Glycogenin Deficiency Causes Polyglucosan Storage. Journal of Clinical Endocrinology & Metabolism. 2020;105(2):557-566.