Dr. Richard Frye, MD, PhD: Understanding the Roles and Sensitivity of Mitochondrial Functioning

For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters. He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopmental disorders. Dr, Richard Frye https://drfryemdphd.com CV https://wparticles.seek2understand.or... Rossingnol Medical Center Facebook   / rossignolmedicalcenter   Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science... Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast... 0:00 Dr. Richard Frye 6:13 Intro into mitochondria & energy production, various disease & dysfunction 11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics 16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain 20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine 26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria 30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation 34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression 42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis 45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm) 54:54 Future Research 59:58 Wrap up, Reviews/Ratings X:   / rps47586   Hopp: https://www.hopp.bio/fromthespectrum email: [email protected]