Seminar 436: 🦠 Microbioma y Cáncer: Cómo la Microbiota Influye en la Carcinogénesis y el Tratamiento

📌 Microbiome and Cancer: Impact on Carcinogenesis and Cancer Treatments In this video, we analyze the role of the microbiome in cancer progression, its influence on the response to chemotherapy, immunotherapy, and radiotherapy, and how its manipulation can improve therapeutic outcomes. ✔️ Microbiota and cancer: relationship with inflammation and tumor genetics ✔️ Dysbiosis: how bacteria can promote or inhibit tumors ✔️ Effect of the microbiome on the efficacy of chemotherapy and immunotherapy ✔️ Potential therapeutic strategies based on microbiota modulation 🔔 Subscribe for more content on oncology and advances in precision medicine. Dr. Julio Minera, Dr. Valeria Cabrera, Dr. Pablo Hernández, Dr. Hugo Castro, @grupomedicoangeles.dr.hugo5602, @centromultidisciplinariode7109, @maestriadeoncologiadeligss7617, #grupoangeles, #hugocastro, #cancerguate, 📌 Chapters with Timestamps 00:00 - Introduction to the microbiome and its relationship with cancer 00:38 - What is the microbiota? Composition and Functions 01:25 - The concept of dysbiosis and its impact on diseases 02:51 - Importance of the metagenome and its interaction with the host 05:10 - Technological advances in the study of the microbiome 06:01 - Influence of the microbiota on the initiation and progression of cancer 07:19 - The "fertile soil" theory and the tumor microenvironment 08:44 - Bacteria involved in carcinogenesis 10:10 - Local and systemic effects of the microbiome on cancer 12:05 - Mechanisms of microbial tumorigenesis 13:46 - Bacterial-induced DNA damage and epigenetic mechanisms 14:28 - Inflammatory pathways and STAT3 signaling in tumor progression 16:09 - Helicobacter pylori and Fusobacterium nucleatum in gastric and colorectal cancer 17:43 - Alterations Cell adhesion and tumor invasion 18:37 - Salmonella and its role in oncogenic mutations 19:25 - Impact of the microbiome on the pharmacokinetics of treatments 22:49 - Microbiome and response to chemotherapy 24:15 - Microbiota and immunotherapy: modulation of PD-1 and CTLA-4 26:01 - Radiotherapy and microbiome protection 27:21 - Future strategies for microbiome manipulation 28:49 - Impact of the microbiome on treatment toxicity and efficacy 30:54 - Relationship between microbiota and immunogenic cell death 32:27 - Conclusions: microbiota as a future therapeutic target