Beta Blockers | Mechanism of Action, Indications, Adverse Reactions, Contraindications

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this cardiovascular pharmacology lecture, Professor Zach Murphy breaks down the essential concepts behind Beta Blockers, focusing on their mechanisms of action, clinical applications, and pharmacologic distinctions across different generations. We begin by reviewing the role of beta-adrenergic receptors (β₁ and β₂) in regulating heart rate, contractility, vascular tone, and bronchodilation. From there, we explore how beta blockers antagonize these receptors, leading to decreased heart rate, myocardial contractility, and renin release, making them effective in treating hypertension, angina, arrhythmias, heart failure, and post-MI management. The lecture categorizes beta blockers by selectivity: • Non-selective (β₁ + β₂): Propranolol, Nadolol • Cardioselective (β₁ only): Metoprolol, Atenolol, Bisoprolol, Esmolol • Mixed α/β blockers: Labetalol, Carvedilol We also cover important clinical considerations, including adverse effects like bradycardia, bronchospasm, fatigue, masking of hypoglycemia, and worsening of acute decompensated heart failure. You’ll learn which agents are best suited for specific conditions based on their receptor profile and pharmacokinetics. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #BetaBlockers #Antihypertensives