Potassium Sparing Diuretics | Mechanism of Action, Indications, Adverse Reactions, Contraindications

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this pharmacology lecture, Professor Zach Murphy breaks down the Potassium-Sparing Diuretics, focusing on their mechanisms, clinical applications, and important side effects—especially their role in preventing hypokalemia when used with other diuretics. We begin by dividing this drug class into two main categories based on their site and mechanism of action in the collecting ducts of the nephron: • Aldosterone antagonists: Spironolactone and Eplerenone—block mineralocorticoid receptors, reducing sodium reabsorption and potassium excretion • Epithelial sodium channel blockers (ENaC inhibitors): Amiloride and Triamterene—directly block sodium channels, preventing sodium reabsorption and potassium loss The lecture reviews key indications including heart failure with reduced ejection fraction (HFrEF), resistant hypertension, primary hyperaldosteronism, hypokalemia, and cirrhosis with ascites. You’ll also learn about off-label uses such as hormonal acne and polycystic ovarian syndrome (PCOS) with spironolactone. We highlight adverse effects such as hyperkalemia, gynecomastia and endocrine effects (with spironolactone), and important contraindications, including renal failure and concurrent use with other potassium-elevating agents. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #PotassiumSparingDiuretics #Diuretics