The Truth About GLP-1s Your Doctor Won't Tell You | Ep. 325

Dr. Jeffrey Gladden sits down with fitness and nutrition expert Autumn Calabrese to unpack the truth about GLP-1 agonists. The conversation most doctors aren't having is about what's actually happening inside your body while the scale goes down. They cover the differences between GLP-1s, GLP-2s, and GLP-3s, why the ghrelin rebound causes most people to regain everything, and how to lose fat while protecting muscle. Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/su... If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/ap... Timestamps 00:44 What Is a Peptide 05:00 You Can't Out-Peptide Bad Habits 06:31 How GLP-1s Affect Your Brain and Gut 11:00 Retatrutide vs. GLP-1s on Energy Expenditure 14:06 The Patient Who Lost 20 Lbs of Pure Muscle 15:00 Perfect Aminos and Creatine for Muscle 21:18 The 5-Day Fasting Mimicking Diet 23:00 How to Build Natural GLP-1 Production 28:30 The Risks No One is Talking about with Unsupervised Use 29:50 Microdosing GLP-1s in Perimenopause 32:00 Sex Hormone Optimization 35:00 Metabolic Rate and Hidden Thyroid Issues Follow Autumn Calabrese: Instagram:   / autumncalabrese   Facebook:   / autumncalabresefitness   Follow Dr. Gladden on Social Media: Instagram: https://www.instagram.com/gladdenlong... LinkedIn:   / gladdenlongevity   𝐆𝐥𝐚𝐝𝐝𝐞𝐧 𝐋𝐨𝐧𝐠𝐞𝐯𝐢𝐭𝐲 𝐏𝐨𝐝𝐜𝐚𝐬𝐭 𝐃𝐢𝐬𝐜𝐥𝐨𝐬𝐮𝐫𝐞𝐬 𝐏𝐫𝐨𝐝𝐮𝐜𝐭𝐢𝐨𝐧 & 𝐈𝐧𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐜𝐞 The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. 𝐌𝐞𝐝𝐢𝐜𝐚𝐥 𝐃𝐢𝐬𝐜𝐥𝐚𝐢𝐦𝐞𝐫 The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. 𝐏𝐨𝐝𝐜𝐚𝐬𝐭 𝐆𝐮𝐞𝐬𝐭 𝐃𝐢𝐬𝐜𝐥𝐨𝐬𝐮𝐫𝐞𝐬 Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. 𝐒𝐩𝐨𝐧𝐬𝐨𝐫𝐬𝐡𝐢𝐩𝐬 & 𝐀𝐟𝐟𝐢𝐥𝐢𝐚𝐭𝐞 𝐃𝐢𝐬𝐜𝐥𝐨𝐬𝐮𝐫𝐞𝐬 To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. 𝐀𝐝𝐝𝐢𝐭𝐢𝐨𝐧𝐚𝐥 𝐍𝐨𝐭𝐞 𝐨𝐧 𝐂𝐨𝐧𝐭𝐞𝐧𝐭 𝐈𝐧𝐭𝐞𝐠𝐫𝐢𝐭𝐲 All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.