Biologicals and Biosimilars in Dermatology - Definition, Classification, Characteristics, Properties

Hi. With this video, we will discuss Biologicals and Biosimilars in Dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel. Introduction - 00:00 Biologicals - 01:18 Classification - 07:51 Monoclonal Antibodies - 08:41 Fusion anti-body proteins - 12:43 Recombinant Human Cytokines and Growth Factors - 16:01 IVIG - 16:44 Biosimilar - 18:10 Biosimilar - Steps for Approval - 27:44 Biosimilar - Preclinical Analytical Assessment - 29:43 Biosimilar - Nomenclature - 31:00 Microheterogeneity - 32:28 Interchangeability - 33:43 Immunogenicity - 38:00 Extrapolation - 39:57 Biomimics - 42:30 Biosimilars FDA approved for Psoriasis - 43:54 Problem A reas for Biosimilars - 45:04 Further Reading - 45:45 Articles for further reading - 1. Constantin MM, Cristea CM, Taranu T, et al. Biosimilars in dermatology: The wind of change. Exp Ther Med. 2019;18(2):911-915. doi:10.3892/etm.2019.7505 2. Gupta V, Khaitan BK. Therapeutic potential of biosimilars in dermatology. Indian J Dermatol Venereol Leprol. 2015;81(5):451-456. doi:10.4103/0378-6323.163706 3. Lebwohl M. Biosimilars in Dermatology. JAMA Dermatol. 2021;157(6):641-642. doi:10.1001/jamadermatol.2021.0219