GLP-1 + Hormones: The Hidden Risk Your Doctor Isn’t Telling You | Episode 29

If you're in midlife and taking a GLP-1 medication like Ozempic, Wegovy, Mounjaro, or Zepbound—and you're also on hormone replacement therapy (HRT)—this is a conversation you need to hear. Because there’s something most women aren’t being told… 👉 These medications may be interacting in ways that affect your hormones, metabolism, and overall safety. In this episode of The Modern Midlife Collective, Dr. Jillian Woodruff and Dr. Ade Akindipe break down the science behind GLP-1 medications and hormone therapy, including how drugs like semaglutide and tirzepatide impact digestion, medication absorption, and weight loss in perimenopause and menopause. You’ll learn how GLP-1s can improve metabolic health, insulin resistance, and visceral fat, while hormone therapy supports estrogen balance, energy, and body composition—and why combining them may lead to even better results. But here’s the critical piece most providers are missing… GLP-1 medications slow gastric emptying, which may reduce the absorption of oral progesterone, potentially impacting endometrial protection and uterine health. This episode connects the dots between hormones, weight loss medications, gut health, and midlife metabolism—so you can make informed, empowered decisions about your care. 💫 💡 In This Episode, We Cover: GLP-1 medications explained (Ozempic, Wegovy, Mounjaro, Zepbound) Hormone replacement therapy (HRT) in perimenopause and menopause The link between estrogen, metabolism, and weight gain in midlife How GLP-1s affect digestion, gut motility, and medication absorption Risks of oral progesterone while on GLP-1 therapy Safer options like transdermal estrogen, progesterone IUD, and vaginal progesterone Muscle loss with GLP-1s and how to protect lean body mass Nutrition, protein intake, and strength training for midlife women 5 essential questions to ask your doctor ✨ Who This Episode Is For: Women in perimenopause or menopause Anyone taking or considering GLP-1 weight loss medications Women on hormone therapy or estrogen therapy Those struggling with weight gain, belly fat, insulin resistance, or low energy Women who want to optimize their metabolic health and longevity 💬 The Bottom Line GLP-1 medications and hormone therapy are two of the biggest tools in modern women’s health—but they don’t work in isolation. Understanding how they interact can help you protect your hormones, metabolism, and long-term health. You deserve care that connects all the dots. 💕 📩 Have Questions? We’d love to hear from you. If you have questions, concerns, or topics you want us to cover, email us at: [email protected] You’re not alone in this—we’re learning, navigating, and thriving together. 💫 #modernmidlifecollective #midlifehealth #glp1 #metabolichealth #highlights