JAK-STATopathies : d’une voie immunitaire à l’autoinflammation et à l’auto-immunité (Partie 1)

Web conference of May 7, 2026 JAK-STATopathies: From an immune pathway to autoinflammation and autoimmunity, by Dr. Jérôme HADJADJ, Internal Medicine Physician at Saint-Antoine Hospital in Paris, whom we thank. Part 2:    • JAK-STATopathies  : Prise en charge thérap...   This webinar is also available in English:    • JAK-STATopathies : from an immune pathway ...   This webinar covers: 00:46 The JAK-STAT pathway: the main cytokine signaling pathway 01:55 General diagram of JAK-STAT signaling 03:18 Pro-inflammatory cytokines and the JAK-STAT pathway 04:37 Exploring the JAK-STAT pathway 06:34 Genetic diseases of the JAK-STAT pathway 07:58 Monogenic JAK-STAT diseases and autoimmunity/autoinflammation 09:09 Gain-of-function mutations in STAT1 10:26 Gain-of-function mutations in STAT3 12:18 Gain-of-function mutations in STAT4 13:26 Gain-of-function mutations in STAT6 14:47 Mutations with JAK1 gain of function 15:39 Loss of function of negative regulators 16:03 SOCS1 haploinsufficiency: cytokine hypersensitivity 17:08 PTPN2 haploinsufficiency: cytokine hypersensitivity 18:03 Diagnosis of JAK-STATopathies 19:44 Conclusions – Part 1 Learn more about this webinar: https://www.fai2r.org/videotheque-par... Rare Autoimmune and Autoinflammatory Disease Healthcare Network Website: https://www.fai2r.org Facebook: /fai2r Instagram: /filiere_fai2r LinkedIn: https://www.linkedin.fr/company/fai2r