Syndromes hyperéosinophiliques (SHE) : du diagnostic à la prise en charge

Webinar of May 14, 2026 Hypereosinophilic Syndromes (HES): From Diagnosis to Management, by Dr. Matthieu Groh (Internal Medicine, Foch Hospital, Suresnes, CRMR for Hypereosinophilic Syndromes), whom we thank. This webinar is also available in English: This webinar covers: 00:42 Mechanisms underlying hypereosinophilia 02:15 HES: What are we talking about? 04:23 Diversity of clinical manifestations 05:34 Dermatological manifestations 06:18 Eosinophilic pneumonias 07:30 Digestive manifestations 08:35 Eosinophilic heart disease 09:37 Coronary vasospasms (Kounis syndrome) 10:51 Vascular involvement and hypereosinophilia 11:35 Eosinophilic vasculitis? 12:54 Epidemiology 14:15 M/LN-eo FIP1L1: PDGFRA 16:24 Other M/LN-eo 17:09 HES with JAK/STAT pathway mutation 18:26 JAK/STAT HES: correlation between mutational status and OS 18:50 JAK/STAT HES: predictive factors for mortality 19:30 3-4+ lymphoid HES: a low-grade T-cell lymphoma 20:22 3-4+ lymphoid HES: clinical presentation 20:49 @cereo.fr in case of diagnostic uncertainty 21:13 EGPA: correlation between ANCA and phenotype 22:00 Analogies between ANCA-negative EGPA and HES 22:38 IgG4-associated "hypereosinophilic" disease 24:02 Treatment: general principles 26:05 Treatment: idiopathic HES 28:26 Mepolizumab in HES: Episode 1 29:54 Mepolizumab in HES: Episode 2 31:14 Mepolizumab in HES: What role? 32:36 Mepolizumab in HES: Real-world efficacy? 33:59 Lymphoid HES: The "gap in the net" 35:09 Lymphoid HES: Targeting AJK/STAT and/or the T-cell clone? 37:13 Treatment: Clonal SHE Learn more about this webinar: https://www.fai2r.org/videotheque-par... Healthcare Network for Rare Autoimmune and Autoinflammatory Diseases Website: https://www.fai2r.org Facebook: /fai2r Instagram: /filiere_fai2r LinkedIn: https://www.linkedin.fr/company/fai2r