Biosensor Technologies: SPR, BLI and DNA Nanolevers - Stephen McLaughlin

Biosensor Technologies: SPR, BLI and DNA Nanolevers Speaker: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK The LMB Biophysics Facility houses a wide range of state-of-the-art and in-house built instruments that enable the molecular characterisation of macromolecular size, shape, mass, stability, binding affinity, dynamics and interaction kinetics. The facility is primarily intended for hands-on research by students, postdocs, and group leaders, who prepare samples and make measurements. Biophysics supports users in advice on experimental techniques and results, training and in collaborative research. In this video, Stephen explains how different biosensors technologies can be used to understand the binding affinity and kinetics of biomolecular interactions. He covers the basis of the different detection methods, immobilisation strategies, experiment set-ups and how data can be analysed. Several applications of each technique are shown. The Biophysics Facility is headed by Stephen McLaughlin, supported by Christopher Batters. Read more about the facility here: https://www2.mrc-lmb.cam.ac.uk/resear... You can find more videos from the LMB 2025 Biophysics Techniques Lecture series here:    • Biophysical Techniques Lecture Series 2025   -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Bluesky: https://bsky.app/profile/mrclmb.bsky.... Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...