Risco residual: LDL controlado, mas ainda com risco de infarto? - Ft. Dr. Eduardo Lima (DozeCast 228

You optimized LDL. You reached the ApoB target. And the patient returns months later with a new event. In this special episode, with support from Novo Nordisk, Diandro Mota and William Batah welcome Dr. Eduardo Lima, PhD in Cardiology from USP, collaborating professor and supervisor of the Cardiology Residency at FMUSP/InCor and National Head of Cardiology for the Americas Network, for a conversation that can redefine how you view residual risk. The thesis is straightforward: atherosclerosis has never been just a cholesterol disease. It is immunometabolic, and subclinical inflammation may be the missing link. What you will learn: 📌 Why ~90% of first heart attacks and strokes are explained by modifiable factors (INTERHEART and INTERSTROKE) and yet we continue to lose patients 📌 How JUPITER showed that elevated ultrasensitive CRP carries risk even with "acceptable" LDL 📌 The almost philosophical question that CANTOS answered: does reducing inflammation without affecting LDL reduce the event? (spoiler: yes) 📌 The return of an old drug to the center of cardiology: colchicine, COLCOT, and LoDoCo2, with their real limitations 📌 The paradigm-breaking POSEIDON data: 4 out of 10 patients with HF have hs-CRP ≥2, and in an almost identical way in HFpEF, HFmrEF, and HFrEF 📌 Why visceral adipose tissue is not a passive storage, but an active immunometabolic organ 📌 IL-6, ziltivekimab, and the future division of residual risk into lipid, thrombotic, metabolic, and inflammatory The most troubling point: the problem may not just be poorly treating inflammation. It's not identifying the inflamed patient. And, according to the POSEIDON profile (obesity, central adiposity, CKD, diabetes, worst NYHA), this patient is not an exception in the office. On the contrary. This episode is for cardiologists, residents, and students who want to stop just looking for residual cholesterol and start seeing residual inflammation. 🔔 Subscribe to the channel and activate the bell so you don't miss the next episodes of DozeCast. #SubclinicalInflammation #CardiovascularRisk #UltrasensitiveCPR #CANTOS #JUPITER #Colchicine #HeartFailure #IL6 #Cardiology #DozeCast #ResidualRisk #Atherosclerosis __________________ Receive weekly didactic reviews of Cardiology on DozeNews PRIME — the lightest and fastest way to stay updated, through the link https://news.dozeporoito.com/dozecast26. 👉 Subscribe now! EXCLUSIVE discount for DozeCast listeners through the link!