Diffuse Large B-Cell Lymphoma | Part 2: Treatment | R-CHOP, O-CHOP, DA-EPOCH-R, Pola-R-CHP, CAR-T

Cancer therapies are constantly changing and can be difficult to get a firm grasp of the many options. In this video I explain the primary therapies used to treat diffuse large b-cell lymphoma (DLBCL). We first discuss the NCCN recommend treatment algorithm. Then we go into some of the specific therapies and regimens used, including R-CHOP, O-CHOP, DA-EPOCH-R, Pola-R-CHP, RICE, MATRIX, and CAR-T. This video is intended to be at the level of a internal medicine resident. Twitter/X: https://x.com/T_Fus/ #lymphoma #cancertherapy #moleculargenetics #hematology #oncology 00:00 Introduction 00:39 Treatment Flowchart 03:16 Overview of Therapies 04:00 R-CHOP 07:43 O-CHOP 09:13 DA-EPOCH-R 12:13 Pola-R-CHP 14:17 CNS Prophylaxis 16:18 CNS Therapy 17:50 CAR-T Therapy 20:06 Outro References: https://www.nejm.org/doi/10.1056/NEJM... https://ashpublications.org/blood/art... https://ashpublications.org/blood/art... https://ashpublications.org/blood/art... https://ascopubs.org/doi/10.1200/JCO.... https://ascopubs.org/doi/full/10.1200... https://pubmed.ncbi.nlm.nih.gov/30501... https://ashpublications.org/blood/art... https://ascopubs.org/action/downloadS... https://www.nejm.org/doi/full/10.1056... https://ashpublications.org/thehemato... https://ashpublications.org/blood/art... https://www.nature.com/articles/bjc20... https://haematologica.org/article/vie... https://www.sciencedirect.com/science... https://ashpublications.org/blood/art... https://www.nejm.org/doi/full/10.1056...