Treating the Root Cause of Fatigue & PEM in Long Covid & ME/CFS: Mitodicure | With Prof. Klaus Wirth

In this second part of the interview with Professor Klaus Wirth, we discuss what needs to happen to make the implications of this research more widely known, what he thinks of viral persistence, and the news about the new drug Mitodicure, which has been designed specifically to counter mitochondrial dysfunction and the cascade of symptoms that follow. Important note regarding sodium/calcium intake for those who have expressed concerns - see below explanation from Prof Wirth himself: "There is (demonstrated) intramuscular sodium rise as a harmful mechanism in skeletal muscle. High intracelluar sodium finally causes calcium overload and mitochondrial damage via reversing the transport mode of the sodium-calcium-exchanger NCX from exporting calcium to importing calcium. On the other hand patients are recommended to take up sufficient sodium to combat hypovolemia and orthostatic intolerance that causes perfusion disturbances and a high level of stress (to desensitize ß2-adrenergic receptors that are so important for activating the Na+/K+ATPase). There is no contradiction. Intracellular (intramuscular sodium) is regulated by ion channels and transporters. Intramuscular sodium in ME/CFS is raised by excitation (sodium channel opening during excitation) and ion transporters (such as NHE1). One cannot lower (harmful elevated) intracellular sodium by restricting sodium intake which would worsen the orthostatic intolerance and the subsequent pathophysiology. Raising sodium intake in the situation of hypovolemia does not raise sodium concentrations in the blood but leads to an expansion of the volume (with no or very little change in the sodium concentration). Patients should take in the recommended amounts of salt – not low and not excessive." Channel Membership (new! 99p!)    / @rundmc1   CHAPTERS: 0:00 Introduction 0:27 How to Get Wider Recognition 2:12 Other Organs Impacted? 4:18 Viral Persistence? 4:55 MDC002 / Mitodicure 6:47 Next Most Important Research 7:37 What Can Patients Do? 8.53 Conclusion 9:26 Skeletor LINKS: Part 1 of the Interview with Prof. Klaus Wirth:    • The Latest Research on Mitochondrial Dysfu...   Key Pathophysiological Role of Skeletal Muscle Disturbance in Post COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Accumulated Evidence (Scheibenbogen / Wirth) - 27 Dec 2024 https://onlinelibrary.wiley.com/doi/1... An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Wirth / Scheibenbogen, Paul) - 22 Nov 2021 https://pubmed.ncbi.nlm.nih.gov/34809... A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors (Wirth / Scheibenbogen) Jun 2020