RNA Therapeutics: The future of personalized medicine

RNA-based therapeutics has the potential to revolutionize healthcare. These therapies directly target the causative agents or pathways of the disease. However, in order to understand the various ways in which RNA-based therapeutics can be used, it is important to understand what they are and the ways in which they can prevent and/or cure diseases. Discussing previous types of research in regard to RNA therapeutics is also vital as new research aims to expand on information previously discovered, to further enhance the idea and find new ways for RNA based therapeutics to be used. RNA-based therapeutics can be useful in treating a plethora of diseases. The effectiveness of personalized medicine with RNA-based therapeutics revolutionizes healthcare and quality of life and will continue to do so as more research is done. Although RNA therapeutics has its challenges, they are continuously evolving and as technology progresses, they hold strong potential to become a very valuable tool in the future of medicine. This video was made by McMaster students Arjun Patel, Konark Patel, Minahil Nadeem, and Vanessa Natareno in collaboration with the McMaster Demystifying Medicine Program Subscribe to the McMaster Demystifying Medicine YouTube channel:    / demystifyingmedicine   This video is provided for general and educational information only. Please consult your health care provider for Information about your health. Copyright McMaster University 2022 #DemystifyingMedicine Suggested Videos: RNA-Based Therapies -    • RNA-Based Therapies   RNA Therapeutics and DNA Editing | Jennifer Doudna -    • RNA Therapeutics and DNA Editing | Jennife...   CRISPR technology is now targeting RNA-based diseases | Patrick Hsu | TEDxSanDiegoSalon -    • CRISPR technology is now targeting RNA-bas...   How to Stop Cancer Using RNA -    • How to Stop Cancer Using RNA   References: AAT Bioquest. (2020, July 22). What are the differences between miRNA and siRNA? Retrieved November 29, 2021, from https://www.aatbio.com/resources/faq-.... Bobbin, M. L., Burnett, J. C., & Rossi, J. J. (2015). RNA interference approaches for treatment of HIV-1 infection. Genome Medicine, 7(1). https://doi.org/10.1186/s13073-015-01... Burnett, J. C., & Rossi, J. J. (2012). RNA-based therapeutics: Current progress and future prospects. Chemistry & Biology, 19(1), 60–71. https://doi.org/10.1016/j.chembiol.20... BioPharm International. (n.d.). Can using RNA simplify gene therapy development? Retrieved November 29, 2021, from https://www.biopharminternational.com.... CB Insights. (2021, February 3). What are mRNA therapies, and how are they used for vaccines? CB Insights Research. Retrieved November 29, 2021, from https://www.cbinsights.com/research/w.... Centers for Disease Control and Prevention. (2021, June 1). About HIV/AIDS. Retrieved November 29, 2021, from https://www.cdc.gov/hiv/basics/whatis.... Davis, M. E., Zuckerman, J. E., Choi, C. H., Seligson, D., Tolcher, A., Alabi, C. A., Yen, Y., Heidel, J. D., & Ribas, A. (2010). Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature, 464(7291), 1067–1070. https://doi.org/10.1038/nature08956 National Cancer Institute. (2021, September 3). Melanoma treatment (PDQ®)–patient version. Retrieved November 29, 2021, from https://www.cancer.gov/types/skin/pat.... Nogrady, B. (2019, October 16). The challenge of delivering RNA-interference therapeutics to their target cells. Nature News. Retrieved November 29, 2021, from https://www.nature.com/articles/d4158.... Song, E., Lee, S.-K., Dykxhoorn, D. M., Novina, C., Zhang, D., Crawford, K., Cerny, J., Sharp, P. A., Lieberman, J., Manjunath, N., & Shankar, P. (2003). Sustained small interfering RNA-mediated humanimmunodeficiency virus type 1 inhibition in primarymacrophages. Journal of Virology, 77(13), 7174–7181. https://doi.org/10.1128/jvi.77.13.717... Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020). Opportunities and challenges in the delivery of mRNA-based vaccines. Pharmaceutics, 12(2), 102. https://doi.org/10.3390/pharmaceutics... Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., & Huang, Y. (2020). The challenge and prospect of mRNA therapeutics landscape. Biotechnology Advances, 40, 107534. https://doi.org/10.1016/j.biotechadv....