Alanine to 2-Bromopropanoic Acid and Ethyl 2-Bromopropanoate
The preparation of (2S)-bromopropanoic acid via the diazotization of L-alanine, followed by Fischer esterification to form ethyl (2S)-bromopropanoate. Original Procedure: Archer, C.; Thomas, N.; Gani, D. Syntheses of (2S,3R)- and (2S,3R)[3-2H]-3-Methylaspartic acid: Slow Substrates for a syn-Elimination by Methylaspartase. Tetrahedron Asymmetry. 1993, 4, 6, 1141-1152. DOI: 10.1016/S0957-4166(00)80221-9 Other References: Thomas, D.; Thomas, J. The gas-phase reaction between methyl chloride and nitrogen dioxide. Trans. Faraday Soc. 1961, 57, 266-278. DOI: 10.1039/TF9615700266 Lepore, S.; Mondal, D.; Li, S.; Bhunia, A. Stereoretentive Halogenations and Azidations with Titanium(IV) Enabled by Chelating Leaving Groups. Angew. Chem. Int. Ed. Engl. 2008, 47, 39, 7511–7514. DOI: 10.1002/anie.200802472 2 Bromopropionic acid from Alanine and Hydrobromic and Sodium Nitrite, Nux,s Channel. • Video Patreon: / corrosion Chapters: 00:00 Introduction 01:43 2-Bromopropanoic Acid Synthesis 09:07 Ethyl 2-Bromopropanoate Synthesis 13:30 Ethyl 2-Bromopropanoate Analysis
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