How to prepare Fortified Eyedrops! | Step-by-Step Guide

𝗔𝗻𝘁𝗶𝗯𝗮𝗰𝘁𝗲𝗿𝗶𝗮𝗹 =========== Fortification means to intensify or strengthen the medication, to achieve adequate drug concentration. Fortified Antimicrobials are not commercially available, thus should be, prepared of optimal constitution in a sterile pharmaceutical dispensary. This video provides guide on topical fortified antibiotic therapy dosage concentration and methodology of preparation of drugs for patients with infectious Keratitis. Acquaintance on Fortified Antimicrobial medication, its appropriate usage and timely intervention will help us to treat most of the microbial Keratitis and prevent the need for surgical intervention. Following are the Fortified Antibiotic preparations. 1.Fortified Vancomycin eye drop 2.Fortified Ceftazidime eye drop 3.Fortified Amikacin eye drop 4.Fortified Imipenem eye drop 𝟭.𝗣𝗿𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗙𝗼𝗿𝘁𝗶𝗳𝗶𝗲𝗱 𝗩𝗮𝗻𝗰𝗼𝗺𝘆𝗰𝗶𝗻(𝟱%) 𝗲𝘆𝗲 𝗱𝗿𝗼𝗽: 𝗥𝗲𝗾𝘂𝗶𝗿𝗲𝗺𝗲𝗻𝘁: ######### A. Injection Vancomycine 500mg B. Two preservative containing lubricating eye drop C. 5ml distilled water D. 5ml syringe 𝗠𝗲𝘁𝗵𝗼𝗱: ######### 𝗦𝘁𝗲𝗽-𝟭: Take 2ml of distilled water 𝗦𝘁𝗲𝗽-𝟮: Inject 2ml into vancomycin injection 𝗦𝘁𝗲𝗽-𝟯: Shake well to mix the contents 𝗦𝘁𝗲𝗽-𝟰: Tale 1ml of moisol from each bottle and discard it 𝗦𝘁𝗲𝗽-𝟱: Now take the entire content of Vancomycin injection and inject 1ml in each moisol bottle 5% Fortified Vancomycin eye drop is prepared Mention the date of preparation on bottle cover 𝗦𝗵𝗲𝗹𝗳 𝗹𝗶𝗳𝗲: 7 days at 4° 𝟮.𝗣𝗿𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗙𝗼𝗿𝘁𝗶𝗳𝗶𝗲𝗱 𝗖𝗲𝗳𝘁𝗮𝘇𝗶𝗱𝗶𝗺𝗲(𝟱%)𝗲𝘆𝗲 𝗱𝗿𝗼𝗽: 𝗥𝗲𝗾𝘂𝗶𝗿𝗲𝗺𝗲𝗻𝘁: ######### A. Injection ceftazidime 1gm B. Preservative containing lubricating eye drops C. 5ml distilled water D. 5ml syringe 𝗠𝗲𝘁𝗵𝗼𝗱: ######### 𝗦𝘁𝗲𝗽-𝟭: Take 4ml of distilled water 𝗦𝘁𝗲𝗽-𝟮: Inject 4ml into Ceftazidime injection 𝗦𝘁𝗲𝗽-𝟯: Shake the contents properly 𝗦𝘁𝗲𝗽-𝟰: Take 1ml of moisol from both the bottles and discard this 1ml 𝗦𝘁𝗲𝗽-𝟱: Take 2ml of the injection 𝗦𝘁𝗲𝗽-𝟲: Insert 1ml in each bottle 5% Fortified Ceftazidime eye drop is prepared Mention the date of preparation on the bottle cover 𝗦𝗵𝗲𝗹𝗳 𝗟𝗶𝗳𝗲: 7 days at 4° 𝟯.𝗣𝗿𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗙𝗼𝗿𝘁𝗶𝗳𝗶𝗲𝗱 𝗔𝗺𝗶𝗸𝗮𝗰𝗶𝗻(𝟮.𝟱%)𝗲𝘆𝗲 𝗱𝗿𝗼𝗽: 𝗥𝗲𝗾𝘂𝗶𝗿𝗲𝗺𝗲𝗻𝘁: ######### A. Injection Amikacin 500mg/2ml B. Amikacin sulphate eye drop C. 5ml Syringe 𝗠𝗲𝘁𝗵𝗼𝗱: ######### 𝗦𝘁𝗲𝗽-𝟭: Take 2ml of amikacin injection and inject it into Aminogen eye drop 2.5% Fortified Amikacin eye drop is prepared Mention the date of preparation on the bottle cover 𝗦𝗵𝗲𝗹𝗳 𝗟𝗶𝗳𝗲: 7 days at 4° 𝟰.𝗣𝗿𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗙𝗼𝗿𝘁𝗶𝗳𝗶𝗲𝗱 𝗜𝗺𝗶𝗽𝗲𝗻𝗲𝗺(𝟭%) 𝗲𝘆𝗲 𝗱𝗿𝗼𝗽: 𝗥𝗲𝗾𝘂𝗶𝗿𝗲𝗺𝗲𝗻𝘁: ######### A. Imipenem + Colistin injection (500mg) B. Two moisol eye drop C. 5ml distilled water D. 5ml syringe 𝗠𝗲𝘁𝗵𝗼𝗱: ######### 𝗦𝘁𝗲𝗽-𝟭: Take 2ml distilled water in a syringe 𝗦𝘁𝗲𝗽-𝟮: Inject in into injection Imipenem 𝗦𝘁𝗲𝗽-𝟯: Shake well 𝗦𝘁𝗲𝗽-𝟰: Take 1ml from each moisol bottle and discard it 𝗦𝘁𝗲𝗽-𝟱: Now take 2ml from injection solution and inject 1ml into each moisol eye drop bottle 𝗦𝘁𝗲𝗽-𝟲: Shake well 1% Fortified Imipenem eye drop is prepared Mention the date of preparation on bottle cover 𝗦𝗵𝗲𝗹𝗳 𝗟𝗶𝗳𝗲: 7 days at 4° Disclaimer: This video is meant for the education of eye specialist. The treatment should be done by ophthalmologist based on own clinical judgment.