SÍNDROME NEFRÓTICO - NEFROLOGÍA - VILLAMEDIC

Nephrotic syndrome is defined as the presence of proteinuria greater than 3.5 g/24h/1.73 m² of body surface area in adults, or a urine protein/creatinine ratio generally greater than 3; in children, it is defined as greater than 40 mg/hour/m² of body surface area. It is accompanied by hypoalbuminemia, edema, and hyperlipidemia. If microalbuminuria has been determined, the value for considering nephrotic syndrome is greater than 2200 mg/24h, or the albumin/creatinine ratio in a single urine sample is greater than 2220 mg/g (greater than 220 mg/mmol). Nephrotic syndrome is caused by increased renal permeability to proteins and is an expression of an alteration in the glomerular filtration barrier. Although it can appear after functional or structural damage to endothelial cells and the basement membrane, in most cases, damage is present in the podocytes, which form part of the visceral layer of Bowman's capsule. Medicine Channel.