TUDCA Benefits, Dosing and Timing

Want to fix your health's root causes? Join my community 👉https://www.skool.com/holistic-health... Dr. Sung's Supplement Store👉https://us.fullscript.com/plans/drjin... 0:00 Intro 0:15 TUDCA 0:45 TUDCA's impact on liver and gallbladder 1:25 Neuroprotection-ALS, Parkinson's, Alzheimer's and Huntington's 1:45 Metabolic improvements 2:13 Eye Health 2:24 Gut microbiome 3:13 Dosage and Timing 3:54 Clinical Applications for TUDCA, HCL and Ox Bile TUDCA (Tauroursodeoxycholic Acid) is a bile acid derivative formed by conjugating taurine with ursodeoxycholic acid (UDCA). It is naturally present in small amounts in human bile and is more commonly found in bear bile (used historically in traditional Chinese medicine). TUDCA is water-soluble and has cytoprotective, anti-apoptotic, and anti-inflammatory properties. It acts primarily by supporting bile flow, preventing bile acid-induced liver injury, and reducing endoplasmic reticulum (ER) stress. Research-Based and Clinical Uses of TUDCA 1. Liver and Gallbladder Health **FDA-approved (UDCA) for Primary Biliary Cholangitis (PBC); TUDCA is a derivative with improved solubility. **Clinical trials show TUDCA improves cholestatic liver diseases, non-alcoholic fatty liver disease (NAFLD), and alcoholic steatohepatitis (ASH) by reducing liver enzyme levels (ALT, AST) and decreasing inflammation. **Mechanism: Enhances bile flow, reduces hydrophobic bile acid toxicity, stabilizes hepatocyte membranes. 2. Neuroprotection TUDCA crosses the blood-brain barrier and has been studied for: **Amyotrophic Lateral Sclerosis (ALS) – Phase II trials (e.g., combining with sodium phenylbutyrate) showed slowed disease progression (FASEB J, 2011; NEJM, 2020). **Parkinson’s and Huntington’s Disease – Preclinical studies support reduced neuronal apoptosis and ER stress. **Alzheimer’s Disease – Animal studies show reduced amyloid β accumulation and improved memory (Front Pharmacol, 2021). 3. Metabolic and Mitochondrial Health **Improves insulin sensitivity and reduces ER stress in obesity and diabetes models (J Clin Invest, 2008). **TUDCA restores mitochondrial function and prevents apoptosis in retinal degeneration, cardiac stress, and muscle atrophy models. 4. Ocular and Retinal Conditions Promising research in retinitis pigmentosa, glaucoma, and retinal ischemia due to neuroprotective and anti-apoptotic effects. 5. Gut-Liver Axis TUDCA modulates gut microbiota, restores intestinal barrier integrity, and reduces inflammatory markers, showing promise in IBD and gut permeability syndromes. There is no standardized timing established across all conditions, but clinical and pharmacokinetic studies offer general recommendations: With meals: TUDCA is best absorbed with dietary fat, so taking it with a meal increases bioavailability. Split doses: Clinical doses (e.g., 500–1500 mg/day) are often divided into 2–3 doses/day to maintain steady plasma levels. Morning and evening: Twice-daily regimens are most common in human studies for liver disease and neurological applications. Want to become Dr. Sung's Patient Office Contact 978 688-6999 https://www.drjinsung.com Email: [email protected] This video is for general information and educational purposes only and does NOT constitute the practice of medicine or other professional health services, including giving of a medical advice. NO doctor-patient relationship is formed. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. You should not make any change in your health regimen or diet before first consulting a physician. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.