Mixed-Mode Chromatography — Optimizing Target Purity and Recovery with Buffer Additives

New biotherapeutic constructs continue to increase in biopharmaceutical development, extending treatment options to a broad range of diseases we face today. These biopharmaceuticals include recombinant proteins, monoclonal antibodies, antibody drug conjugates, bispecifics, viruses, and virus-like particles to mention a few. A simple, straightforward approach to the production of these biomolecules is required to meet the current demand for process efficiency and economics. Innovative chromatographic methods facilitate the achievement of desired drug purity and yield. This webcast showcases the unique selectivity of mixed-mode chromatography and detail the use of buffer additives for optimal target purity and yield. Overview: -The synergistic effects of ligand structural moieties -The modulation of ligand–biomolecule interactions with buffer pH, conductivity, and additives -The intuitive mechanism-based chromatography method development Learn more at https://www.bio-rad.com/en-us/process... #Chromatography #Purification #Biotherapeutics Subscribe to the Bio-Rad channel: https://www.youtube.com/user/BioRadLi... We Are Bio-Rad. Our mission: To provide useful, high-quality products and services that advance scientific discovery and improve healthcare. At Bio-Rad, we are united behind this effort. These two objectives are the driving force behind every decision we make, from developing innovative ideas to building global solutions that help solve our customers' greatest challenges. Connect with Bio-Rad Online: Website: http://www.bio-rad.com/ LinkedIn:   / 1613226   Facebook:   / biorad   Twitter:   / bioradlifesci   Instagram: @BioRadLabs Snapchat: @BioRadLabs ©2021 Bio-Rad is a trademark of Bio-Rad Laboratories, Inc. in certain jurisdictions. All trademarks used herein are the property of their respective owner. Music used by permission granted by royalty-free license from Pond5.com