nanoHUB-U Biodesign L4.1: Cell Dynamics - Biological Oscillations I

Table of Contents: 00:00 Biological Oscillations I 00:10 This lecture … 00:32 Possible response of an unperturbed dynamic system 02:01 Oscillations / Rhythms Occur in Nature at all time scales 03:21 Periodic 04:17 Oscillations May be More complex, e.g. Bursting 05:38 Oscillations appear as a closed trajectory in the phase plane. 06:32 Limit Cycle 07:52 Stable Limit cycle 09:10 biochemical oscillators 10:05 Basic design requirements for biochemical system to oscillate 11:16 Basic design requirements for biochemical system to oscillate 12:59 Basic design requirements for biochemical system to oscillate 13:45 Negative feedback common motifs to produce biochemical oscillators 14:41 3. Sufficient nonlineary: Sources of nonlinearity 16:26 4. Dependence on parameters 20:32 For further reading 21:14 Coming up… This video is part of the nanoHUB-U course "Biological Engineering: Cellular Design Principles" currently offered on nanoHUB-U (https://nanohub.org/courses/biod) or on EdX (https://www.edx.org/course/biological...) Cellular Design Principles is a five week course that explores the design principles underlying mechanisms of cellular and biomolecular functions such as cell architecture, energy storage and conversion, sensing and signaling, communication, time keeping, molecular synthesis, memory, and motility. Emphasis will be placed on the chemical, physical, and mathematical features that determine the performance of the biological device. Topics cover both cellular/biochemical processes and molecular/genetic circuits. Examples are presented from reverse engineering of natural systems and design of new synthetic systems.