nanoHUB-U Biodesign L4.2: Cell Dynamics - Biological Oscillations II

Table of Contents: 00:00 Biological Oscillations II 00:10 This Lecture 00:42 Your Biological Day Night Clock 01:27 Internal Clock 02:28 Circadian Rhythms Everywhere! 03:12 The Circadian Clock: 04:54 Clock Definitions 05:07 Clock Definitions - Phase Shifts 05:34 Basis of the Clock? What is the cellular mechanism? 06:35 Genes? 07:22 Seymour Benzer 08:42 Genes Involved? 09:38 Biochemistry of Period 11:02 Mathematical Model 13:01 Other genes? 13:39 Drosophila PER TIM Model 14:57 Mathematical Model of Period / Timeless 15:34 example of simulation output 16:33 Light Entrainment 18:08 For Further Reading 18:28 Coming Up This video is part of the nanoHUB-U course "Biological Engineering: Cellular Design Principles" currently offered on nanoHUB-U (https://nanohub.org/courses/biod) or on EdX (https://www.edx.org/course/biological...) Cellular Design Principles is a five week course that explores the design principles underlying mechanisms of cellular and biomolecular functions such as cell architecture, energy storage and conversion, sensing and signaling, communication, time keeping, molecular synthesis, memory, and motility. Emphasis will be placed on the chemical, physical, and mathematical features that determine the performance of the biological device. Topics cover both cellular/biochemical processes and molecular/genetic circuits. Examples are presented from reverse engineering of natural systems and design of new synthetic systems.