#88 How Life Works Beyond Genes: the New Biology of Meaning with scientist and author Philip Ball

Send a love message (https://www.buzzsprout.com/2229994/fa...) Beyond Genes, Toward Meaning & Care, But Rigorously Andrea Hiott hosts British science writer Philip Ball (former Nature editor; trained chemist and physicist) to discuss his book How Life Works and why the popular idea “it’s all in the genes” is untenable. Ball argues biology is shifting beyond mechanistic, bottom-up “blueprint” metaphors toward a view of organisms as open, adaptive informational systems with complex genotype–phenotype relations, constant interaction across levels (genes to ecosystems), and robust behavior emerging from “committee-like” molecular collectives. They discuss why biology has avoided purpose, teleology, and meaning, yet living systems make contextual value judgments and goal-directed decisions, with continuity from cells to human minds and emotions, emphasizing embodiment and symbiosis. Ball links these themes to his prostate cancer diagnosis while finishing the book, reflecting on mortality, persistence of patterns and information through art and writing, and the open-endedness of life and evolution, ending with love as a real evolved capacity. 00:00 Welcome and Guest Intro 00:35 Why Biology Is Shifting 02:09 Cancer, Meaning, and Patterns 04:37 Challenging Gene Determinism 11:03 Beyond the Machine Metaphor 17:52 Purpose and Teleology in Life 23:58 Messiness and Higher-Level Causation 31:54 Meaning Making in Cells 38:10 Embodiment and the Mind-Body Link 41:20 Embodied Minds 42:23 Nested Bodies and Meaning 43:52 Molecular Caring and Committees 45:02 Physics of Collectivity 47:19 Universality From Traffic to Cells 51:11 Leaky Layers in Living Systems 53:20 Beyond E. coli to Elephants 55:49 Caring as a New Metaphor 57:44 Symbiosis Parasites and Affordances 01:03:23 Brains Agency and Emotions 01:08:10 Mortality and Whirlpools of Meaning 01:15:42 Uniqueness Open-Ended Evolution 01:18:25 Love as Evolutionary Reality TRANSCRIPT Andrea Hiott: Hello, everyone. Welcome to Love and Philosophy. This is Andrea Hiott, and I’m glad you’re here. Today is a really special conversation, which I had quite some months ago, back in February, with a writer who is one of my favorites, Philip Ball. He is a British science writer. He used to be the editor at Nature for over 20 years. He’s trained as both a chemist and a physicist, and he’s written a lot of really good books. Critical Mass was a prize-winning book, and there’s also H2O, The Music Instinct, and the one we’re talking about here, How Life Works. Let me tell you a little bit about this book. It comes at a moment when I think biology is really shifting. It’s a shift that’s been going on for a while, but it’s at an important moment now where this mechanistic gene-first story we’ve been telling — the one that says you are your genes, you are your DNA, the selfish gene, that whole idea — is really changing a lot. The idea of the body as a machine assembled from the bottom up, that story is coming apart. But it’s interesting because we don’t want to just flip to the opposite, to reject all that came before. That’s what this book is doing that’s so interesting, and also this conversation. I think you’ll hear it. We’re trying to hold a certain tension because even though that story is coming apart, it’s not that everything is wrong about it. The hope is not to flip into the opposite, but rather to hold the tension and to really open up a new space about how we actually think about what life is and what we are. We have more ways to communicate and more ways to study this that can help us get more rigorous even as we also open up. So that’s what we’re trying to do in this conversation. It gets a little bit messy — that’s a word I’m always using, but in a good way — because we’re trying to talk about a lot of very hard things here, and we’re also trying to talk about them in a way that isn’t the usual way. You’ll hear that Philip is very articulate about this. He’s even better in the book, so I really highly recommend it. He’s also written some very beautiful essays, and one of them, which is in Nautilus, is about how at the end of writing this book he got diagnosed with cancer. We get to that by the end of this conversation because he’s come through well. He had surgery. All is good. It’s all gone. But there was a time when it was very tense for him, and he was writing this book about life, so can you imagine? He was really having these questions pressed on him directly as he had been thinking about life and trying to understand what it was. There’s something very moving about that. What he came to through this was that we are made of this material that’s changing all the time, but what persists are these patterns that come through us, or are in the world with us, or that we create and give to the world that then go on without us. It’s not that they’re floating around in the air. It’s that I can read this book again...