Anna Nowak | Effect of Electromagnetic Fields on Permeation and Skin Accumulation of Ibuprofen

Anna Nowak, Pomeranian Medical University in Szczecin, Poland Title: Effect of Electromagnetic Fields on Permeation and Skin Accumulation of Ibuprofen Abstract: Ibuprofen is frequently used as a non-steroidal anti-inflammatory drug, demonstrating potential for transdermal drug delivery systems. It is used to treat pain, inflammation, and fever. Its action primarily involves inhibiting the synthesis of prostaglandins responsible for the development of the inflammatory response. Thanks to its well-known pharmacological profile and wide clinical application, it is a frequent subject of research into new routes and forms of drug administration. Magnetic fields are increasingly being used in biomedical research as a factor that can modulate biological processes. It has been shown that appropriately selected field parameters can affect the permeability of tissues, including the skin. Magnetic fields are increasingly being considered as a potential tool for supporting drug penetration through human skin. Our research assessed the effect of selected types of electromagnetic fields (EMFs) on both drug transport across the skin barrier and drug accumulation in the skin. The study was conducted ex vivo using a Franz diffusion cell. The donor phase contained 1% ibuprofen dissolved in 70% ethanol. The acceptor fluid was a PBS solution at pH 7.4. The penetration study was conducted for 8 hours. The acceptor fluid was sampled after 0.5, 1, 2, 3, 5, and 8 hours. The drug concentration in the acceptor fluid was determined using High Performance Liquid Chromatography (HPLC). Various types of magnetic fields were used in the study, including static, pulsed, oscillating, and rotating, with positive and negative polarity. This study provides a comprehensive assessment of the effects of various electromagnetic fields (EMFs) on transdermal ibuprofen delivery potentials as well as drug embedding in the skin. This research was supported by the National Science Centre (Poland) under the OPUS 25 grant no. UMO-2023/49/B/ST8/00605. Keywords: penetration skin, electromagnetic field, ibuprofen, Franz diffusion cell Biography: Prof. Anna Nowak is a University Professor at the Pomeranian Medical University in Szczecin, employed at the Department of Cosmetic and Pharmaceutical Chemistry. Her main research interests include the use of plant materials and substances derived from them in cosmetology and dermatology. Furthermore, she has been researching the permeation of active substances from plants and anti-inflammatory drugs through the skin for many years. She is the author of over 100 publications, primarily on the use of natural materials in medicine and on the permeability of active substances through natural and artificial membranes and drug accumulation within them. #WCCE2026 #chemistry #chemistryconferences #catalysis #analyticalchemistry #organicchemistry #greenchemistry #nanotechnology #environmentalchemistry #inorganicchemistry #organometallics #materialscience #syntheticchemistry #biochemistry #greenchemistry #medicinalchemistry #chemicalresearch #chemicalengineering