Alzheimer's, Sleep Disturbance, and Brain Health

Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain’ article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence. DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC https://www.ncbi.nlm.nih.gov/pmc/arti... Sleep well — and reduce your risk of dementia and death - Harvard Health https://www.health.harvard.edu/blog/s... APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Text https://alzres.biomedcentral.com/arti... N3 Phase of Sleep. https://chat.openai.com/chat Understanding Delta Brain Waves And Sleep https://www.sixstepstosleep.com/under... N3: Slow Wave Sleep | Sleepopolis https://sleepopolis.com/education/n3-... Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagram https://www.researchgate.net/figure/S... A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagram https://www.researchgate.net/figure/4... Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagram https://www.researchgate.net/figure/H... Frontiers | Perivascular Spaces, Glymphatic System and MR https://www.frontiersin.org/articles/... Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink https://link.springer.com/article/10.... Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System https://www.frontiersin.org/articles/... Neuroglia Lab : Glymphatics and virchow-robin space http://visnu528.blogspot.com/2014/09/... Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology https://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipedia https://en.wikipedia.org/wiki/Aquapor... Astrocyte - Wikipedia https://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocytes https://neuropathology-web.org/chapte.... Blood-brain barrier | RIT https://www.rit.edu/spotlights/blood-... The Blood-Brain Barrier | Morphology of Nervous System https://sisu.ut.ee/histology/blood-br... Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Text https://fluidsbarrierscns.biomedcentr... The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagram https://www.researchgate.net/figure/T... External Carotid Artery: Anatomy & Branches | Study.com https://study.com/academy/lesson/exte... Cervical Node Mets fron Occult Primary http://www.aboutcancer.com/cervical_n... Donate to the Front Line Covid-19 Critical Care Alliance, Inc. https://flccc.net/donate Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.