Lattice vs Granular Corneal Dystrophy: Spot the Difference at the Slit Lamp

In this high-yield video, we simplify the TGFBI-related stromal corneal dystrophies — focusing on Granular Corneal Dystrophy (GCD1, GCD2/Avellino) and Lattice Corneal Dystrophy (LCD1). 🔬 Key Concepts Covered: • Genetics: TGFBI mutations (R555W in GCD1, Arg124His in GCD2, R124L in GCD3, LCD1 variants) • Pathology: Hyaline (Masson trichrome+) vs Amyloid (Congo red+, apple-green birefringence) • Clinical: Slit-lamp signs, recurrent erosions, age of onset, disease progression • Diagnostics: Confocal & AS-OCT depth, histology, IC3D classification • Management: PTK, DALK, PK outcomes, recurrence, refractive surgery contraindications (LASIK/SMILE) 📍 Perfect for: Ophthalmology students, FRCS / FICO candidates, cornea specialists, and vision researchers. ⚠️ Clinical Pearl: Always screen for TGFBI mutations before keratorefractive surgery to prevent post-LASIK exacerbation in GCD2/Avellino dystrophy. 📚 References: Kanski, The “Cornea E-Book” edited by Jay H. Krachmer, Mark J. Mannis, and Edward J. Holland EyeWiki, PubMed & major corneal dystrophy reviews. 🔔 Subscribe to Insight Ophthalmology for concise, exam-oriented eye concepts every week #GranularCornealDystrophy #LatticeCornealDystrophy #TGFBI #StromalCornealDystrophy #OphthalmologyHighYield #InsightOphthalmology Join this channel to get access to perks:    / @insightophthalmology