17 Principles of Targeted Therapy

In this video, Dr. Dan introduces the concept of targeted therapies, first by reviewing the biology of cancer and detailing the four gastroesophageal adenocarcinoma molecular subsets of the Cancer Genome Atlas (TCGA): Chromosomal Instability (CIN), Microsatellite Instability (MSI-H), Genomically Stable (GS), and Ebstein Bar Virus (EBV+). Dr. Dan then discusses the two main types of targeted therapies - antibodies and small molecules. He discusses the mechanisms of action of various targeted therapies, highlighting those FDA-approved agents used in gastroesophageal cancer, including trastuzumab, trastuzumab-deruxtecan, and ramucirumab, as well as targeted therapies that are expected to soon be available, zolbetuximab and regorafenib. For online second opinions for patients in or visiting Illinois, please visit: catenacciconsulting.com