Metabolismo de Nucleotídeos - Aula para Ensino Superior

This lesson is about Nucleotide Metabolism, which are the building blocks of our DNA and RNA. Throughout the lesson, we will cover the three main areas you need to master: 1- De novo synthesis: How the cell builds purines and pyrimidines from scratch. 2- Salvage Pathways: The molecular recycling system that conserves the cell's energy. 3- Degradation: How the body eliminates excesses and why purines leave us with uric acid as a legacy, while pyrimidines are converted into soluble products. We will also discuss fundamental clinical correlations that frequently appear on exams, such as Gout, Lesch-Nyhan Syndrome, and the mechanism of action of strategic drugs (Allopurinol, Methotrexate, 5-Fluorouracil, and Hydroxyurea) used in the treatment of cancer and autoimmune diseases. 📌 What you will learn in this lesson: 06:29 - "Summary" using the Concept Map 14:24 - De novo synthesis of purines (ATP and GTP): The role of PRPP and the GPAT enzyme 22:33 - Purine degradation, hyperuricemia, and the pathophysiology of gout 29:28 - Purine salvage pathway and the purine nucleotide cycle in muscle 30:26 - Clinical cases: Lesch-Nyhan syndrome 33:47 - Pyrimidine synthesis: Differences, CPS II, and the formation of UMP, CTP, and dTMP 41:55 - Degradation and salvage of pyrimidines 43:33 - The bridge to DNA: How ribonucleotide reductase (RNR) works 48:46 - References I hope this explanation makes sense to you! If you enjoyed the lesson, don't forget to like, subscribe to the channel, and share the video on your class's WhatsApp to give it a boost. Leave your questions in the comments and I'll answer them all! Hugs and kisses, and see you later! 🧬✨