Metabolismo de la LDL [Origen, función y captación por endocitosis] | Bioquímica

#LDL #cholesterol #VLDL ►Content: 0:00 Intro 0:17 Structure of LDL 2:05 Origin of LDL 6:42 LDL Uptake 9:39 Summary ►Additional Data: -ApoB-100 is one of the largest and most insoluble human proteins and has a molecular weight greater than 550 kDa and more than 4,500 amino acid residues. -In the fasting state, VLDL fatty acids are primarily from adipose tissue. In this case, VLDL will primarily go to the heart and skeletal muscle. -The enzyme that esterifies cholesterol with fatty acids is called acyl-CoA:cholesterol acyltransferase (ACAT). -Thyroid hormone regulates the number of LDL receptors on cells. ►Sources used to create the video: -Venugopal SK, et al. Biochemistry, Low Density Lipoprotein. Treasure Island (FL): StatPearls Publishing; 2021. Available at: https://www.ncbi.nlm.nih.gov/books/NB... -Karagiannis AD, et al. How low is safe? The frontier of very low LDL cholesterol. European Heart Journal. 2021;42(22):2154-2169. Available at: https://sci-hub.ru/10.1093/eurheartj/... -Schoeneck M, Iggman D. The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials. Nutrition Metabolism & Cardiovascular Diseases. 2021;31(5):1325-1338. Available at: https://sci-hub.ru/https://doi.org/10... -Chandra NC. A comprehensive account of insulin and LDL receptor activity over the years: A highlight on their signaling and functional role. Journal of Biochemistry and Molecular Toxicology. 2021;35(9):e22840. Available at: https://sci-hub.ru/10.1002/jbt.22840 -Roberts BS, et al. Characterization of lipoprotein lipase storage vesicles in 3T3-L1 adipocytes. Journal of Cell Science. 2022;135(5):jcs258734. Available at: https://pubmed.ncbi.nlm.nih.gov/34382...