Stop Doing This With Central Lines? New JAMA Trial Changes Practice. TWPCCM

Three new papers. Three common bedside problems. One recurring theme: evidence is challenging the clinical defaults we’ve accepted for years. In this week’s episode of This Week in Pulmonary & Critical Care Medicine (TWPCCM), Dr. Aladdin Sagar reviews: • A JAMA randomized trial showing that 4% tetrasodium EDTA locking solution reduced central venous catheter complications with a number needed to treat of just 20. • The largest network meta-analysis ever performed in non-cystic fibrosis bronchiectasis, comparing macrolides, brensocatib, inhaled corticosteroids, and other anti-inflammatory therapies. • A comprehensive CHEST review on invasive candidiasis in critically ill patients, including why blood cultures miss approximately half of cases and how newer diagnostics may improve outcomes.