Fenebrutinib Update. Clinical Trial Results, Liver Disease, and Death

This video is an update on the investigational multiple sclerosis drug fenebrutinib. 3 randomized trials have been completed (FENhance 1, FENhance 2, and FENtrepid). We review the risk of elevation of liver enzymes and an unexpected increase in deaths in those taking the drugs. Selected Sources: Fenebrutinib Achieves Primary End Point in Phase 3 Head-to-Head Trial vs Teriflunomide in Relapsing MS: https://www.neurologylive.com/view/fe... Roche reports another phase 3 multiple sclerosis win, but deaths add to safety questions: https://www.fiercebiotech.com/biotech... A diagram showing the potential role of Bruton’s Tyrosine Kinase inhibiting drugs (tolebrutinib, evobrutinib, masitinib) in Multiple Sclerosis: https://link.springer.com/article/10.... Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study: https://pubmed.ncbi.nlm.nih.gov/40683... Roche pill succeeds in another MS study, but approval questions linger: https://www.biopharmadive.com/news/ro... [Ad hoc announcement pursuant to Art. 53 LR] Roche's fenebrutinib confirms its potential as first and only BTK inhibitor for relapsing and primary progressive MS in third positive Phase III study (FENhance 1): https://www.roche.com/media/releases/... Fenebrutinib Maintains Low Disease Activity in Relapsing Multiple Sclerosis: Results from the FENopta Trial Open-label Extension (P8-1.005): https://www.neurology.org/doi/10.1212... ACTRIMS 2026 Virtual Neurology IR Event (roche): https://assets.roche.com/f/176343/x/4... Comment or ask questions below! I would be happy to answer! Subscribe on YouTube for more videos every Wednesday! Make video requests in the comments section! Check out my book “Resilience in the Face of Multiple Sclerosis” FREE on Amazon: https://amazon.com/dp/B07WP7H5LK It's about 5 people with MS who live incredible lives, the science and psychology of resilience, mindfulness, and ho’oponopono. Paperback priced to generate $0 royalty. Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research. Follow me on twitter:   / brandon_beaber   Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link:    • Video   T he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.