Anaerobic Hydroxylation of C–H Bonds Enabled by Photoexcited Nitroarenes with Joshua Paolillo

In this Research Spotlight episode, Joshua Paolillo (Parasram lab, NYU) joins us to share his work on C-H hydroxylation using photo excited nitroarenes. Key reference: J. Am. Chem. Soc. 2023, 145, 2794. https://doi.org/10.1021/jacs.2c13502 Additional references (in order of appearance): Cramer, J., et. al. J. Med. Chem. 2019, 62, 8915. Dalton, T et. al. ACS Cent. Sci. 2021, 7, 245; Zhao, J., et al. Nat. Chem. 2019, 11, 213; Shuler, W. G. et. al. Org. Lett. 2017, 19, 4790. Wise, D. E.; Gogarnoiu, E. S. et. al. J. Am. Chem. Soc. 2022, 144, 15473 Hamilton, G. A., et. al. J. Chem. Soc. D. 1970, 1390; Severin, T., et. al. J. Org. Chem. 1998, 63, 1138; Wang, B., et. al. Chem. Sci. 2022, 13, 11074.