Cuando el antioxidante se vuelve antitumoral: vitamina C a dosis farmacéuticas - Óscar Aguilera

🔴 👉👉 👉👉 MASTER'S DEGREE IN INTEGRATIVE NUTRITIONAL SUPPLEMENTATION Based on Evidence: https://tienda.esi.academy/producto/m... Óscar Aguilera, oncology researcher, explains how vitamin C at pharmacological doses (ascorbate at 5 mM) eliminates chemoresistant cancer cells (triple-negative lung, colon, and breast) in vitro and slows (in vivo) colon tumors with KRAS mutations by: Delocalizing RAS from the membrane → blocking the entire MAPK cascade (MEK → ERK). Inhibiting PKM2 and GLUT-1 (key enzymes of the Warburg metabolic switch). Reducing glycolytic gene transcription and proliferative signaling. Key Results: Tumor viability greater than 90%; normal cells are barely altered. Mice with KRAS-mutated xenografts show a 49% reduction in tumor volume in 15 days. Vitamin C can be an adjuvant in tumors resistant to cetuximab and traditional chemotherapy. It is proposed to explore derivatives or combinations based on this mechanism for selective therapies without toxicity. 00:00 Initial idea: “Let’s try vitamin C” 00:18 Assay with KRAS-mutated cells: massive cell death 01:06 Approach: MAPK pathway and Warburg metabolism 02:10 Overexpressed GLUT-1 and PKM2 in colon cancer 03:06 Vitamin C ↓ GLUT-1 and PKM2 (Western blot) 04:32 Blockade of phosphorylated MEK/ERK 05:32 RAS delocalization (immunofluorescence) 06:14 Mouse xenografts: –49% tumor in 15 days 07:09 Proposed mechanism: ascorbate ≠ energy for the tumor “Ferrari” 08:16 Published conclusions (OncoTarget 2016) 08:46 Future research and derived molecules 09:58 Final message and availability of the Article *This video is for informational and educational purposes only. The information provided does not constitute medical advice, recommendations, or counseling of any kind. Use of the information in this video or any linked materials is at the user's own risk. The content of this video is not intended as a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay seeking medical advice for any medical condition they may have and should seek the assistance of their healthcare professionals for such conditions. ---------------------------------------------------------------------------------------------------------- 🔔 SUBSCRIBE TO THE CHANNEL 👇🏼👇🏼 https://www.youtube.com/c/EscueladeSa... 📍 VISIT OUR WEBSITE → https://www.esi.academy/ ✉ EMAIL: [email protected] 📲 CONTACT US VIA WHATSAPP → +34 627 069 186 ✅ MORE FREE INFORMATION ON HEALTH, NUTRITION, SUPPLEMENTATION, AND INTEGRATIVE MEDICINE AT: • TELEGRAM: https://t.me/escueladesaludintegrativ... • LINKEDIN:   / esi-academy   • FACEBOOK:   / escueladesaludintegrativa   • INSTAGRAM: https://www.instagram.com/esi.academy...