ATP Synthase Explained (PO Ratios, Fo & F1 Subunits, C-ring) | Clip

Welcome to Science With Tal! In this video, we will cover how the enzyme ATP synthase produces ATP and as a result sustains life. We will discuss the structure of the protein, how the proton gradient is utilized to rotate the c-ring and how this rotation is coupled to the formation of ATP. Here is the link for the full discussion:    • Carbohydrate & Fat Metabolism Explained | ...   You can consult the PDF of the metabolic map here: https://drive.google.com/file/d/1_NKQ... To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section. TIMESTAMPS 0:00 Introduction 0:18 ATP synthase structure 2:55 Proton flow & C ring rotation 4:55 Beta subunits conformations 6:15 ATP making process & PO ratios 11:00 Regulation 12:44 Conclusion RESOURCES Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource) Textbooks 1. Lodish: Molecular Cell Biology (9th ed., 2022) 2. Voet: Fundamentals of Biochemistry (5th ed., 2016) Scientific articles 3. Webb: Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations (2015) https://pubmed.ncbi.nlm.nih.gov/25985... 4. Crocher: Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding (2017) https://pubmed.ncbi.nlm.nih.gov/27802... 5. Revel: Electron microscopy of glycogen (1964) https://pubmed.ncbi.nlm.nih.gov/14187... 6. McCommis: Mitochondrial pyruvate transport: a historical perspective and future research directions (2015) https://www.ncbi.nlm.nih.gov/pmc/arti.... 7. Škerlová: Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion (2021) https://pubmed.ncbi.nlm.nih.gov/34489... 8. Denton: The hormonal regulation of pyruvate dehydrogenase complex (1996) https://pubmed.ncbi.nlm.nih.gov/8869747/ 9. Baradaran: Crystal structure of the entire respiratory complex I (2013) https://www.ncbi.nlm.nih.gov/pmc/arti... 10. Maier: The crystal structure of a mammalian fatty acid synthase (2008) https://pubmed.ncbi.nlm.nih.gov/18772... 11. Saltiel: Insulin signaling in health and disease (2021) https://pubmed.ncbi.nlm.nih.gov/33393... 12. Rahman: Role of Insulin in Health and Disease: An Update (2021) https://pubmed.ncbi.nlm.nih.gov/34203... 13. Gao: α-cell electrophysiology and the regulation of glucagon secretion (2023) https://pubmed.ncbi.nlm.nih.gov/37159... CREDITS Writing: Tal Klimenko Voice: Tal Klimenko Animations: Tal Klimenko Drawings: Tal Klimenko Editing: Tal Klimenko Introductory jingle: Thierry Du Sablond Conclusion music: lukrembo - sunflower (   • lukrembo - sunflower  )