Lecture11 - Protein Language Models - MLCB24

Playlist: https://tinyurl.com/MLCBlectures Notes: https://tinyurl.com/MLCB24notes Lecture Slides: https://www.dropbox.com/scl/fi/0fdbvx... Lecture Chapter: https://www.dropbox.com/scl/fi/ne3s8a... 0:00 Parallels of NLP and Protein language models 9:02 The protein alphabet 13:49 Multiple sequence alignments 17:14 Mutation effect prediction 23:22 Beyond multiple sequence alignments 28:12 Training masked language models 37:57 Model evaluation 44:14 Model embeddings 56:24 Attention maps 59:05 Protein design 1:00:51 Case study on viral evolution