Metabesity 2022: Priority Scientific Topics in Aging

Mitochondria Dysregulation and the Integrated Stress Response in Inflammaging and Cellular Senescence The integrated stress response (ISR), a key mechanism underlying the pathogenesis of neurodegenerative disease, is being recognized as a novel player in cellular senescence. Recent studies highlight a key role of dysregulated mitochondria in driving inflammaging and defective immunity. Join this session to discuss emerging evidence on the role of mitochondria bioenergetics on inflammatory responses and the effects of the ISR on the aging process. Moderator: Ana Maria Cuervo, MD, PhD, Professor, Department of Developmental & Molecular Biology, Department of Medicine, Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases Discussants: Ana Maria Cuervo, PhD Doug Wallace, MD, PhD, Director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia, Michael and Charles Barnett Endowed Chair in Pediatric Mitochondrial Medicine and Metabolic Diseases, Children's Hospital of Philadelphia Hyung Don Ryoo, PhD, Professor, Department of Cell Biology New York University School of Medicine Luigi Ferrucci, MD, PhD, Scientific Director, National Institute on Aging October 10, 2022