ANAFILAXIA

Anaphylaxis is a severe, rapidly developing, and potentially life-threatening hypersensitivity reaction characterized by respiratory, cardiovascular, cutaneous, and/or gastrointestinal involvement. ⚠️🔥 It requires immediate clinical diagnosis and urgent treatment with intramuscular epinephrine, the cornerstone of management. In this video, you will learn: 🧬 Pathophysiology: massive activation of mast cells and basophils mediated by IgE and release of mediators such as histamine and tryptase. 👩‍⚕️ Key diagnostic criteria: acute onset with skin/mucosal involvement + respiratory or cardiovascular involvement, or exposure to a known allergen with multisystemic symptoms. 💉 First-line treatment: IM epinephrine in the thigh (0.01 mg/kg, max 0.5 mg in adults), repeatable every 5–15 minutes. 🩹 Comprehensive management: IV fluids, antihistamines, bronchodilators, and observation to prevent relapses. 🧪 Biomarkers: the usefulness of serum tryptase in diagnostic confirmation. ⚠️ Complications and prevention: biphasic reaction and indication for EpiPen. “Medicine as you’ve never been taught it before.” 💙 Subscribe to Medicursos, the course tailored just for you. #Anaphylaxis #Allergy #Emergencies #ACLS #Medicourses #Adrenaline #AnaphylacticShock #IgE #InternalMedicine #WAO Check out my new medical courses page: https://medicursos.thinkific.com Become a member of this channel to enjoy exclusive benefits:    / @doctorjuanefreng   0:00 Introduction 0:32 Epidemiology 0:51 Etiology 1:49 Pathophysiology 4:46 Clinical Presentation 6:15 Diagnosis 8:10 Treatment 11:52 Summary #science #medicine #student #physiology #enarm #usmle #amboss #ambossmed #study #anatomy #pathology Remember that this channel does not constitute medical advice. For any questions, concerns, or worries, please contact the appropriate professional. It is always best to consult a doctor. The content presented here is for educational purposes only; the user is responsible for its application.